Twinkie began her tutelage in music under the direction of her mother, very early in life. Twinkie credits her musical gifts to God and recognizes her mother as her greatest inspiration. From the age of thirteen, she began touring nationally with her mother, ministering and training choirs in three-part vocal harmony. In 1967, she made her recording debut as a featured vocalist alongside her mother. Clark attended Howard University.
Twinkie has produced albums for several choirs and traveled the world abroad as an evangelist, workshop facilitator, and music educator. She taught organ, piano and vocals for several years at “The Clark Conservatory”.